Profhilo Structura is a non-surgical injectable that uses IBSA’s patented NAHYCO hybrid hyaluronic acid technology to target and regenerate the deep subcutaneous fat layers of the face — a mechanism the manufacturer calls “lipolifting.” Unlike traditional dermal fillers that add artificial volume, this pure hyaluronic acid injectable physically restructures deflated fat cells to naturally lift sagging jowls, correct midface hollowing, and counter facial volume depletion — including from rapid weight loss (often called “Ozempic Face”) — with minimal downtime.
What Is Profhilo Structura?
While skin boosters hydrate the epidermis and dermal fillers alter bone-adjacent structural shadows, Profhilo Structura is formulated specifically to remodel the superficial fat compartments of the face. As we age, these fat pads thin out, fragment, and descend, causing structural flattening. A 2024 clinical review of Profhilo Structura describes the product as targeting patients with either hypotrophy (thinning) of fat compartments in the preauricular area — clinically termed “sinkers” — or jowl sagging from fat loss in the preauricular and zygomatic areas, termed “saggers,” with treatment producing both a lateral tightening and lipolifting effect through adipose tissue restoration.
How Profhilo Structura Works
Formulated with a total of 90mg of pure, thermally stabilized hyaluronic acid per 2ml syringe, the compound comprises:
- 45mg of High Molecular Weight HA (H-HA): acts as an immediate, high-viscosity structural scaffolding to lift descended tissues.
- 45mg of Low Molecular Weight HA (L-HA): delivers sustained bio-remodeling to trigger deep, continuous cellular renewal.
When introduced into the sub-dermal adipose plane, it signals deflated fat cells toward firmer, more youthful behaviour, tightening the superficial fat layers so they can once again support the weight of the skin.
What Makes Structura Different From Traditional Fillers
Traditional dermal fillers are cross-linked with synthetic agents (like BDDE) to create dense, stationary gels that physically fill empty space and stay where injected. Profhilo Structura is chemically pure, with zero cross-linking agents. Instead of creating a single synthetic volume block, it diffuses across the fat layers, stimulating your own biological tissue to lift and re-anchor itself. Fillers are better suited to precise, localized shaping (lips, chin projection, cheekbone definition); Structura is better suited to restoring the overall structural cushion of the face.
Benefits of Profhilo Structura
Restore Facial Volume Loss
It works deeply within the structural fat pads to gently expand and plump out hollow, sunken areas without creating a round, over-filled appearance.
Improve Facial Contours
By reinforcing the preauricular area near the ears and the cheek arches, it sharpens natural profiles and balances facial proportions.
Lift Sagging Skin
The tightening of the underlying fat layers exerts an upward mechanical pull on the superficial skin, correcting structural tissue descent.
Stimulate Natural Collagen Production
The high concentration of thermally bonded hyaluronic acid triggers neocollagenesis (new collagen production) and elastin synthesis, improving skin density and elasticity from within — a mechanism shared with other collagen biostimulator treatments, though Structura’s primary action is on the fat layer rather than the dermis alone.
Who Is Suitable For Profhilo Structura?
Profhilo Structura is generally recommended from the mid-30s onward, with candidates in their 40s and beyond — once fat compartment loss becomes more visible as part of the natural signs of aging — often showing the most noticeable improvement. Good candidates typically fall into one of these profiles:
Sunken Cheeks & Hollow Face (“Sinkers”)
Ideal for individuals whose primary aging trait is structural loss of facial fat, leading to deep facial hollowing and a gaunt appearance.
Sagging Lower Face & Jowls (“Saggers”)
Highly effective for individuals whose superficial fat pads have migrated downward due to gravity, creating prominent jowls and a blurry, undefined jawline.
Weight Loss-Related Facial Hollowing
An option for individuals with rapid volume depletion in the midface and temples following significant weight loss or medical weight-loss treatment (the appearance often termed “Ozempic Face“).
Areas Treated With Profhilo Structura
- Cheeks: re-elevates deflated, flattened cheek fat compartments to restore a youthful curve.
- Mid-face: fills in the hollow spaces below the cheekbones where volume drops out.
- Temples: restores lost volume in hollow temples, a common early sign of facial fat loss.
- Preauricular area: supports the fat compartment just in front of the ear, improving lateral tightening.
- Jawline & lower face: tightens sagging lateral tissues along the lower facial border and redefines the jowls for a sharper profile.
Profhilo Structura Treatment Procedure
Consultation
Your aesthetic physician maps your specific aging phenotype (sinker or sagger) and checks skin laxity to plot the optimal entry points.
Injection Technique
Unlike the 5-point BAP (Bio Aesthetic Points) needle technique used for original Profhilo, Structura is administered using a blunt-tipped cannula. The doctor creates a tiny entry point near the cheek arch, gently gliding the cannula through the subcutaneous fat layer to deposit the product smoothly.
Treatment Duration
The procedure takes roughly thirty minutes, making it a convenient walk-in, walk-out treatment.
Aftercare
Because a cannula is used, surface trauma is minimal, and you can return directly to your routine. Standard aftercare involves avoiding strenuous exercise, facial compression, and high heat for forty-eight hours.
Profhilo Structura Results Timeline
Week 2
The formulation’s elastic modulus (G’) delivers a subtle, immediate mechanical tightening effect as the product spreads evenly under the tissue.
Week 4
Skin quality and deep firmness begin to shift noticeably as the hybrid hyaluronic acid complex stimulates tissue remodeling inside the fat cells.
Week 8
Following the second recommended session, structural lifting, cheek volume projection, and jawline definition reach their peak.
How Long Does Profhilo Structura Last?
Visible lifting and tissue restoration results typically persist for nine to twelve months after completing the initial loading phase, after which a single-syringe maintenance treatment is usually recommended.
Profhilo Structura vs Profhilo
| Feature | The Original Profhilo | Profhilo Structura |
|---|---|---|
| Target layer | Superficial dermis (skin layer) | Subcutaneous fat (adipose layer) |
| Delivery tool | 5-point BAP needle technique per side | Blunt-tipped cannula technique |
| Primary focus | Skin hydration, fine lines, crepey texture | Deep structural lifting, jowl correction, volume hollowing |
| Best for | Dull, thinning skin across face, neck, and neckline | Sunken cheeks, weight loss hollowing, sagging lower face |
Many patients combine both — Structura to lift the deep fat compartments, and original Profhilo to treat superficial skin thinning and fine lines — as part of a single facial rejuvenation plan. See our full Profhilo vs Profhilo Structura comparison for a deeper breakdown of which one fits your concern.
Profhilo Structura Price in Malaysia
A single 2ml syringe of authentic Profhilo Structura in Malaysia typically ranges from RM 2,800 to RM 3,200. Because it’s a genuine IBSA (IBSA Farmaceutici Italia) product, always confirm you’re receiving authentic Profhilo Structura from a licensed clinic — counterfeit or diverted HA products carry real safety risks.
Factors Affecting Cost
Cost varies based on the location of the aesthetic centre (such as premier districts within Kuala Lumpur, Bangsar, or Petaling Jaya) and the credentialing level of your medical injector.
Number of Sessions Required
The foundational protocol requires a loading phase of two sessions spaced roughly four weeks apart to establish long-term structural fat restoration.
Side Effects & Downtime
Profhilo Structura requires virtually zero downtime. Because it is highly biocompatible and non-cross-linked, the body accepts the product readily. The primary side effects are limited to mild, temporary swelling, local tenderness, or light bruising around the cannula entry point, which typically resolve within twenty-four to seventy-two hours.
Frequently Asked Questions
Is Profhilo Structura a type of filler?
No, it is not a traditional dermal filler. While fillers use cross-linked chemical compounds to create synthetic volume in localized pockets, Profhilo Structura consists of pure hyaluronic acid that diffuses throughout the subcutaneous fat layer to bio-remodel and support your own natural tissues.
How many syringes of Profhilo Structura do I need?
The clinical protocol requires one 2ml syringe per session. A complete initial treatment cycle consists of two sessions spaced about one month apart, meaning two syringes total to build the foundational structural lift.
Can I combine Profhilo Structura with the original Profhilo?
Yes. Because they target different structural levels, your doctor can administer Structura to lift the deep fat compartments and use original Profhilo to treat superficial skin thinning and fine lines.
Is the injection process painful?
Discomfort is low. Topical numbing cream or a local anesthetic block is applied to the single cannula entry point beforehand, and because the blunt cannula glides through the fat layer where there are few pain receptors, the treatment is typically felt as light, comfortable pressure.
How quickly will I see results from Structura?
Subtle lifting and firmness can often be seen within the first two weeks as the high-viscosity hybrid complex stabilizes, with the fuller structural restoration developing around week eight, one month after the second session.
Who should not get Profhilo Structura?
As with other hyaluronic acid injectables, it’s generally not recommended during pregnancy or breastfeeding, or for those with active skin infections in the treatment area or a known HA allergy. A doctor’s assessment during consultation will confirm suitability.
