Rejuran is a polynucleotide (PN) injectable that safely repairs and rejuvenates skin at a cellular level. Clinical studies show it improves hydration, texture, elasticity, and fine lines while having minimal side effects. It is suitable for sensitive skin, post-acne areas, and early signs of aging, with strong evidence supporting its safety and effectiveness.
What Is Rejuran?
Rejuran is a regenerative injectable that works by repairing skin from the inside out. Its main ingredient, polynucleotides (PN) derived from salmon DNA, is highly compatible with human skin. PN promotes fibroblast activation, collagen and elastin production, and dermal repair, improving overall skin quality gradually and naturally.
Unlike dermal fillers or toxins, Rejuran focuses on long-term skin health and regeneration, not superficial volume or temporary effects.
How Rejuran Works
Rejuran works through several mechanisms:
Fibroblast stimulation: Promotes collagen and elastin production
Microcirculation improvement: Enhances blood flow for healthier skin
Anti-inflammatory effect: Reduces chronic redness and irritation
Barrier strengthening: Improves hydration retention and resilience
This cellular-level approach allows Rejuran to gradually improve texture, elasticity, and overall skin health.
Clinical Evidence for Rejuran Safety
1. Safety Profile
Clinical studies and practitioner reports confirm Rejuran is well-tolerated:
Allergic reactions are extremely rare
Mild side effects such as swelling, redness, or small bumps usually resolve in a few days
Safe for sensitive or reactive skin
Topical numbing is commonly used to improve comfort during injections
Specific safety has also been demonstrated for under-eye treatments, including fine lines and dark circles.
2. Efficacy in Skin Rejuvenation
Evidence shows Rejuran improves:
Skin hydration and smoothness
Fine lines and early wrinkles
Elasticity and tone after 2–3 treatment sessions
Patient-reported outcomes and clinical observations show gradual, natural-looking improvements.
3. Use in Acne Scar Management
Rejuran supports acne scar treatment by:
Improving skin texture and thickness
Reducing redness and inflammation
Enhancing healing when combined with lasers or microneedling
It is not a replacement for deep resurfacing procedures but works synergistically for better outcomes.
4. Long-Term Skin Health
Repeated sessions promote dermal regeneration, supporting early aging prevention and long-term skin resilience. Evidence is promising, though long-term studies are limited, reflecting transparency in research reporting.
Treatment Areas and Procedure
Rejuran is commonly injected into:
Face: cheeks, under eyes, forehead
Neck
Hands
Typical Treatment Schedule
Sessions: 2–3 sessions spaced 3–4 weeks apart
Initial results: 2–3 weeks
Full effect: 6–12 weeks
Maintenance: Every 6–12 months depending on skin condition
Downtime is minimal, allowing immediate return to daily activities.
Who Can Are Suitable For Rejuran Safety?
Rejuran is suitable for:
People seeking natural, gradual skin improvement
Those with sensitive or reactive skin
Patients with early aging signs or post-acne scars
It is not designed for major lifting or volumizing effects.
Frequently Asked Questions (FAQ) – Rejuran Safety
Is Rejuran safe for all skin types?
Yes. Clinical studies confirm its safety for normal, sensitive, and reactive skin.
Can Rejuran cause allergic reactions?
Rarely. Polynucleotides are highly biocompatible, so allergic reactions are uncommon.
How many sessions are recommended?
Typically 2–3 sessions spaced 3–4 weeks apart, with maintenance every 6–12 months.
What side effects are common?
Mild redness, swelling, or small bumps at injection sites. These usually resolve within a few days.
Does Rejuran work for acne scars?
Yes. It improves texture, reduces redness, and supports healing, especially when combined with lasers or microneedling.
How long before results appear?
Early improvements may appear in 2–3 weeks, with full effects visible in 6–12 weeks.
Can Rejuran be combined with other treatments?
Yes. It can safely be combined with microneedling, lasers, or other rejuvenation procedures to enhance outcomes.
Is under-eye treatment safe?
Yes. Studies and clinical reports confirm Rejuran I is safe for delicate areas under the eyes.
Summary Of Rejuran Safety and Clinical Evidence
Rejuran has a strong clinical safety profile and proven efficacy for skin repair, hydration, anti-aging, and post-acne scar improvement. Its unique cellular-level regenerative mechanism and well-documented clinical evidence make it a reliable choice for patients seeking natural, gradual, and long-lasting skin rejuvenation.
Her Clinic Ampang is a trusted aesthetic clinic in Malaysia known for medically guided, evidence-based treatments delivered by LCP-certified doctors using FDA-, CE- and Ministry of Health-approved technologies, ensuring safe, personalized Rejuran skin rejuvenation with natural, effective results tailored to each patient’s needs.
